In The News:
Chronobiology and Chronomedicine: From Molecular and Cellular Mechanisms to Whole Body Interdigitating Networks
Interview: Chronobiology
Modern Medicine is Too Reliant on Short-Term Studies, The Atlantic
Prediction & Prevention, Circulatory and Respiratory Health
Chronobiology:
Resolution of the SIRMCE Conference
Cosinor technique:
Cosinor-based rhythmometry, 2014
Chronomics analysis toolkit (CATkit), 2016
Application to blood pressure analysis (slides)
A legacy in Time:
Franz Halberg's motto, "Measure what is measurable and render measurable in time what as yet is not" (Omnia metire quaecumque licet et immensa ad mensuram tempestive redige), has also been attributed to Galileo according to Giovanni dell' Acqua, the late professor of medicine at Catholic University in Rome.
Related Links:
Chronobiology
Definition: Science objectively quantifying and investigating mechanisms of biologic time structure, including rhythmic manifestations of life. See full definition...
Chronomics (from Greek chronos, time, and Greek nomos, rule)
Definition: Science objectively quantifying and investigating influences from the broad environment on biological processes, notably in relation to human physiology and pathology. See full definition...
Mission
To serve as an expert facility for research and education in chronobiology as it applies to cardiology
Vision
To use timing according to rhythms (chronobiologic principles) for assessing cardiovascular health, detect pre-disease early, and optimize treatment administration schedules, in order to reduce the number of people who die of preventable heart attacks and strokes
To understand how blood pressure and heart rate vary in response to stimuli in everyday life for health surveillance and maintenance
To explore how solar cycles and changes in the Earth’s radiation environment affect human physiology as their impact may have implications for long-term missions in space
2019 Annual Scientific Report published in Leibnitz Society of Sciences
Recent Publications:
Cornelissen G, Hirota T. Chronobiology and Chronomedicine. From Molecular and Cellular Mechanisms to Whole Body Interdigitating Networks. Royal Society of Chemistry. 2024; 668 pp. https://doi.org/10.1039/9781839167553
Cornelissen G, Watanabe Y, Beaty LA, Otsuka K. Toward a personalized chronotherapy of blood pressure. Biomed J 2025; 48 (5): 100849. https://doi.org/10.1016/j.bj.2025.100849
Otsuka K, Cornelissen G, Beaty LA, Mukai C. Circadian rhythm changes in space. Chapter 13 in: Waisberg E, Ong J, Lee AG (Eds). Fundamentals of Space Medicine and Clinical Technology. 2026; pp. 201-225. https://doi.org/10.1016/B978-0-443-32904-3.00021-2
Gubin D, Weinert D, Stefani O, Otsuka K, Borisenkov M, Cornelissen G. Wearables in chronomedicine and interpretation of circadian health. Diagnostics (Basel) 2025; 15 (3): 327. https://doi.org/10.3390/diagnostics15030327
Gubin D, Kolomeichuk S, Danilenko K, Stefani O, Markov A, Petrov I, Voronin K, Mezhakova M, Borisenkov M, Shigabaeva A, Boldyreva J, Petrova J, Weinert D, Cornelissen G. Light exposure, physical activity, and indigeneity modulate seasonal variation in NR1D1 (REV-ERBα) expression. Biology 2025; 14 (3): 231. https://doi.org/10.3390/biology14030231
Gubin D, Stefani O, Cornelissen G. Light hygiene for circadian health: A molecular perspective. Front Biosci (Landmark Ed) 2025; 30 (7): 39097. https://doi.org/10.31083/FBL39097
Plonka N, Atkinson M, McCraty R, Cornelissen G, Turner AC, Ragulskis M, Vainoras A. Global study of long term heart rhythm synchronization in groups. Sci Rep 2024; 14: 28627 https://doi.org/10.1038/s41598-024-79264-8
Seizer L, Schiepek G, Cornelissen G, Loechner J. A primer on sampling rates of ambulatory assessments. Psychological Methods. 2024. https://doi.org/10.1037/met0000656
Otsuka K, Murakami S, Okajima K, Shibata K, Kubo Y, Gubin DG, Beaty LA, Cornelissen G. Appropriate circadian-circasemidian coupling protects blood pressure from morning surge and promotes human resilience and wellbeing. Clinical Interventions in Aging 2023; 18: 755–769. https://doi.org/10.2147/CIA.S398957
Cornelissen G. Applications of cosinor rhythmometry in pharmacology. Journal of Pharmacokinetics and Pharmacodynamics 2021; 48: 339–359. https://doi.org/10.1007/s10928-021-09748-x
Gubin D, Neroev V, Malishevskaya T, Cornelissen G, Astakhov SY, Kolomeichuk S, Yuzhakova N, Kabitskay Y, Weinert D. Melatonin mitigates disrupted circadian rhythms and improves ganglion cells function in glaucoma. J Pineal Res 2021; 70 (4): e12730. doi: 10.1111/jpi.12730 https://doi.org/10.1111/jpi.12730
Cornelissen Guillaume G, Gubin D, Beaty LA, Otsuka K. Some near- and far-environmental effects on human health and disease with a focus on the cardiovascular system. International Journal of Environmental Research and Public Health 2020. doi:10.3390/ijerph17093083 https://doi.org/10.3390/ijerph17093083
Saka F, Cornelissen G. Chronobiologic assessment of the effect of the DASH diet on blood pressure. Journal of Human Hypertension 2021; 35: 678–684. https://doi.org/10.1038/s41371-020-00408-0
Lusczek ER, Parsons LS, Elder J, Harvey SB, Skube M, Muratore S, Beilman G, Cornelissen-Guillaume G. Metabolomics pilot study identifies desynchronization of 24-hour rhythms and distinct intra-patient variability patterns in critical illness: A preliminary report. Front Neurol 2020; 11: 533915. https://doi.org/10.3389/fneur.2020.533915
Cornelissen G, Watanabe Y, Beaty LA, Turner AC, Sothern R, Siegelova J, Breus T, Gubin D, al-Abdulgader AA, McCraty R, Otsuka K. As-one-goes blood pressure and heart rate monitoring: a chronobiologic approach with applications in clinical practice and basic science. Cardiology & Vascular Research 2021; 5(1): 1-10. https://DOI.org/10.33425/2639-8486.S1-1003
Sletten J, Lund A, Ebbing C, Cornélissen G, Aßmus J, Kiserud T, Albrechtsen S, Kessler J. The fetal circadian rhythm in pregnancies complicated by pregestational diabetes is altered by maternal glycemic control and the morning cortisol concentration. Chronobiology Int. 2019; 36 (4): 481-492. https://doi.org/10.1080/07420528.2018.1561460
Singh RB, Hristova K, Fedacko J, El-Kilany G, Cornelissen G. Chronic heart failure: a disease of the brain. Heart Failure Reviews 2019; 24 (2): 301-307. https://doi.org/10.1007/s10741-018-9747-3
Cornelissen G. Metabolic syndrome, adiponectin, sleep, and the circadian system. EBioMedicine 2018; 33: 20-21. https://doi.org/10.1016/j.ebiom.2018.06.013
Gubin D, Nelaeva AA, Uzhakova AE, Hasanova YV, Cornélissen G, Weinert D. Disrupted circadian rhythms of body temperature, heart rate and fasting blood glucose in prediabetes and type 2 diabetes mellitus. Chronobiology International 2017; 34 (8):1136-1148. https://doi.org/10.1080/07420528.2017.1347670
Otsuka K, Cornélissen G, Halberg F. Chronomics and Continuous Ambulatory Blood Pressure Monitoring – Vascular Chronomics: From 7-Day/24-Hour to Lifelong Monitoring. Tokyo: Springer Japan, 2016, 870 + lxxv pp. 10.1007/978-4-431-54631-3. ISBN:9784431546313, 4431546316 https://link.springer.com/book/10.1007/978-4-431-54631-3
Key Collaborators:
- Professor Kuniaki Otsuka, MD, PhD, Chronomics and Gerontology;
- Professor Jarmila Siegelova, MD, Physiotherapy and Rehabilitation, St Anna Teaching Hospital, Masaryk University, Brno, Czech Republic
- Professor Denis Gubin, MD, PhD, Medical University, Tyumen, Russia; and Tyumen Cardiology Research Center, Russian Academy of Sciences, Tomsk, Russia
- Associate Professor Lyazzat Gumarova, PhD, Al-Farabi Kazakh National University, Almaty, Kazakhstan
- Dr Ram B Singh, MD, Halberg Hospital and Research Institute, Centre of Nutrition and Heart Research, Moradabad, India Associate Professor
- Yoshihiko Watanabe, MD, PhD, Medicine, Tokyo Women’s Medical University, Medical Center East, Tokyo, Japan Members of the International Project on The BIOsphere and the COSmos – BIOCOS (coordinated at the Halberg Chronobiology Center)
- Members of the IEEE Twin Cities Phoenix Project
- Engr. Larry A Beaty serves as adviser and consultant to the Halberg Chronobiology Center
- Drs Francine and Julia Halberg are advisory board members of the Halberg Chronobiology Center
Activities:
Multi-Ethnic Study of Atherosclerosis (MESA)
Mini Symposium Remembering Franz Halberg
May 19, 2017
Noninvasive Methods in Cardiology, Brno, Czech Republic
European Space Weather Week Conference, Brussels, Belgium
Presenting Keynote, Cornelissen
Invited Speech
Conference on Chronomedicine, 2015, Ahamabad, India
Presentation, Cornelissen
Presentation, Lee Gierke
Conference on Chronomedicine, 2016, Lucknow, India
Presentation, Cornelissen
Presentation, Lee Gierke
CardioPalooza (IBP dept) posters
2014: Lyazzat Gumarova
2014: Cathy Lee Gierke
2015: James Fleming
2016: Shahrukh Rizvi
2016: Tony Tran
2016: Cathy Lee Gierke
2017: Lyazzat Gumarova
2017: Zainab Farah
2019: Lyazzat Gumarova
MN Stroke Conference, MN Dept of Health
2016: Poster, Germaine Cornelissen
2017: Presentation, Germaine Cornelissen
Gordon Conference on Chronobiology, Girona, Spain
2015: Poster, Cathy Lee Gierke
University of Minnesota • Mayo Building • Mail Code 8609 • 420 Delaware Street SE • Minneapolis, MN 55455