Measure what is measurable

In The News:

Book:  Chronobiology and Chronomedicine: From Molecular and Cellular Mechanisms to Whole Body Interdigitating Networks

Interview: Chronobiology

Modern Medicine is Too Reliant on Short-Term Studies, The Atlantic

Prediction & Prevention, Circulatory and Respiratory Health


Chronomics and Continuous Ambulatory Blood Pressure Monitoring

Introduction to Chronobiology

Health Watch

Saving Lives

Resolution of the SIRMCE Conference

Cosinor technique:

Cosinor-based rhythmometry, 2014

Chronomics analysis toolkit (CATkit), 2016

Sphygmochron analysis video

Application to blood pressure analysis (slides)

A legacy in Time:

Franz Halberg's motto, "Measure what is measurable and render measurable in time what as yet is not" (Omnia metire quaecumque licet et immensa ad mensuram tempestive redige), has also been attributed to Galileo according to Giovanni dell' Acqua, the late professor of medicine at Catholic University in Rome.

Related Links:

Integrative Biology & Physiology

Lillihei Heart Institute

Institute for Engineering in Medicine


Science objectively quantifying and investigating mechanisms of biologic time structure, including rhythmic manifestations of life. more...

Chronomics (from Greek chronos, time, and Greek nomos, rule)

Science objectively quantifying and investigating influences from the broad environment on biological processes, notably in relation to human physiology and pathology. more...


To serve as an expert facility for research and education in chronobiology as it applies to cardiology


  • To use timing according to rhythms (chronobiologic principles) for assessing cardiovascular health, detect pre-disease early, and optimize treatment administration schedules, in order to reduce the number of people who die of preventable heart attacks and strokes

  • To understand how blood pressure and heart rate vary in response to stimuli in everyday life for health surveillance and maintenance

  • To explore how solar cycles and changes in the Earth’s radiation environment affect human physiology as their impact may have implications for long-term missions in space

2023 Annual Scientific Report

2022 Annual Scientific Report

2021 Annual Scientific Report

2020 Annual Scientific Report

2019 Annual Scientific Report published in Leibnitz Society of Sciences


Recent Publications:

Cornelissen G, Hirota T. Chronobiology and Chronomedicine. From Molecular and Cellular Mechanisms to Whole Body Interdigitating Networks. Royal Society of Chemistry. 2024; 668 pp. https://doi.org/10.1039/9781839167553

Gubin D, Danilenko K, Stefani O, Kolomeichuk S, Markov A, Petrov I, Voronin K, Mezhakova M, Borisenkov M, Shigabaeva A, Yuzhakova N, Lobkina S, Weinert D, Cornelissen G. Blue light and temperature actigraphy measures predicting metabolic health are linked to melatonin receptor polymorphism. Biology 2024, 13, 22. https://doi.org/10.3390/biology13010022

Otsuka K, Cornelissen G, Kubo Y, Shibata K, Mizuno K, Aiba T, Furukawa S, Ohshima H, Mukai C. Methods for assessing change in brain plasticity at night and psychological resilience during daytime between repeated long-duration space missions. Sci Rep 2023; 13: 10909. https://doi.org/10.1038/s41598-023-36389-6

Otsuka K, Murakami S, Okajima K, Shibata K, Kubo Y, Gubin DG, Beaty LA, Cornelissen G. Appropriate circadian-circasemidian coupling protects blood pressure from morning surge and promotes human resilience and wellbeing. Clinical Interventions in Aging 2023; 18: 755–769. https://doi.org/10.2147/CIA.S398957

Gubin D, Neroev V, Malishevskaya T, Kolomeichuk S, Cornelissen G, Yuzhakova N, Vlasova A, Weinert D. Depression scores are associated with retinal ganglion cells loss. Journal of Affective Disorders 2023; 333: 290-296. https://doi.org/10.1016/j.jad.2023.04.039

Gubin D, Neroev V, Malishevskaya T, Kolomeichuk S, Weinert D, Yuzhakova N, Nelaeva A, Filippova Y, Cornelissen G. Daytime lipid metabolism modulated by CLOCK gene is linked to retinal ganglion cells damage in glaucoma. Applied Sciences 2022; 12(13): 6374 https://doi.org/10.3390/app12136374

Otsuka K, Cornelissen G, Furukawa S, Shibata K, Kubo Y, Mizuno K, Aiba T, Ohshima H, Mukai C. Unconscious mind activates central cardiovascular network and promotes adaptation to microgravity possibly anti-aging during 1-year-long spaceflight. Sci Rep 2022; 12: 11862. https://doi.org/10.1038/s41598-022-14858-8

Cornelissen G. Applications of cosinor rhythmometry in pharmacology. Journal of Pharmacokinetics and Pharmacodynamics 2021; 48: 339–359. https://doi.org/10.1007/s10928-021-09748-x

Gubin D, Neroev V, Malishevskaya T, Cornelissen G, Astakhov SY, Kolomeichuk S, Yuzhakova N, Kabitskay Y, Weinert D. Melatonin mitigates disrupted circadian rhythms and improves ganglion cells function in glaucoma. J Pineal Res 2021; 70 (4): e12730. doi: 10.1111/jpi.12730 https://doi.org/10.1111/jpi.12730

Neroev V, Malishevskaya T, Weinert D, Astakhov YS, Astakhov SY, Kolomeichuk S, Cornelissen G, Kabitskaya Y, Boiko E, Nemtsova I, Bogdanova D, Gubin D. Disruption of 24-hour rhythm in intraocular pressure correlates with retinal ganglion cell loss in glaucoma. International Journal of Molecular Sciences Int J Mol Sci 2021; 22: 359. https://doi.org/10.3390/ijms22010359

Cornelissen Guillaume G, Gubin D, Beaty LA, Otsuka K. Some near- and far-environmental effects on human health and disease with a focus on the cardiovascular system. International Journal of Environmental Research and Public Health 2020. doi:10.3390/ijerph17093083 https://doi.org/10.3390/ijerph17093083

Saka F, Cornelissen G. Chronobiologic assessment of the effect of the DASH diet on blood pressure. Journal of Human Hypertension 2021; 35: 678–684. https://doi.org/10.1038/s41371-020-00408-0

Lusczek ER, Parsons LS, Elder J, Harvey SB, Skube M, Muratore S, Beilman G, Cornelissen-Guillaume G. Metabolomics pilot study identifies desynchronization of 24-hour rhythms and distinct intra-patient variability patterns in critical illness: A preliminary report. Front Neurol 2020; 11: 533915. https://doi.org/10.3389/fneur.2020.533915

Cornelissen G, Watanabe Y, Beaty LA, Turner AC, Sothern R, Siegelova J, Breus T, Gubin D, al-Abdulgader AA, McCraty R, Otsuka K. As-one-goes blood pressure and heart rate monitoring: a chronobiologic approach with applications in clinical practice and basic science. Cardiology & Vascular Research 2021; 5(1): 1-10. https://DOI.org/10.33425/2639-8486.S1-1003

Sletten J, Lund A, Ebbing C, Cornélissen G, Aßmus J, Kiserud T, Albrechtsen S, Kessler J. The fetal circadian rhythm in pregnancies complicated by pregestational diabetes is altered by maternal glycemic control and the morning cortisol concentration. Chronobiology Int. 2019; 36 (4): 481-492. https://doi.org/10.1080/07420528.2018.1561460

Singh RB, Hristova K, Fedacko J, El-Kilany G, Cornelissen G. Chronic heart failure: a disease of the brain. Heart Failure Reviews 2019; 24 (2): 301-307. https://doi.org/10.1007/s10741-018-9747-3

Otsuka K, Cornelissen G, Kubo Y, Shibata K, Hayashi M, Mizuno K, Ohshima H, Furukawa S, Mukai C. Circadian challenge of astronauts’ unconscious mind adapting to microgravity in space, estimated by heart rate variability. Scientific Reports 2018; 8 (1): 10381. https://doi.org/10.1038/s41598-018-28740-z

Sletten J, Cornelissen G, Assmus J, Kiserud T, Albrechtsen S, Kessler J. Maternal exercise, season and sex modify the daily fetal heart rate rhythm. Acta Physiologica 2018; 224 (2): e13093. https://doi.org/10.1111/apha.13093

Cornelissen G. Metabolic syndrome, adiponectin, sleep, and the circadian system. EBioMedicine 2018; 33: 20-21. https://doi.org/10.1016/j.ebiom.2018.06.013

Gubin D, Nelaeva AA, Uzhakova AE, Hasanova YV, Cornélissen G, Weinert D. Disrupted circadian rhythms of body temperature, heart rate and fasting blood glucose in prediabetes and type 2 diabetes mellitus. Chronobiology International 2017; 34 (8):1136-1148. https://doi.org/10.1080/07420528.2017.1347670

Otsuka K, Cornélissen G, Halberg F. Chronomics and Continuous Ambulatory Blood Pressure Monitoring – Vascular Chronomics: From 7-Day/24-Hour to Lifelong Monitoring. Tokyo: Springer Japan, 2016, 870 + lxxv pp. 10.1007/978-4-431-54631-3. ISBN:9784431546313, 4431546316   https://link.springer.com/book/10.1007/978-4-431-54631-3


Key Collaborators: 

• Professor Kuniaki Otsuka, MD, PhD, Chronomics and Gerontology;

• Professor Jarmila Siegelova, MD, Physiotherapy and Rehabilitation, St Anna Teaching Hospital, Masaryk University, Brno, Czech Republic

• Professor Denis Gubin, MD, PhD, Medical University, Tyumen, Russia; and Tyumen Cardiology Research Center, Russian Academy of Sciences, Tomsk, Russia

• Associate Professor Lyazzat Gumarova, PhD, Al-Farabi Kazakh National University, Almaty, Kazakhstan

• Dr Ram B Singh, MD, Halberg Hospital and Research Institute, Centre of Nutrition and Heart Research, Moradabad, India

• Associate Professor Yoshihiko Watanabe, MD, PhD, Medicine, Tokyo Women’s Medical University, Medical Center East, Tokyo, Japan

• Members of the International Project on The BIOsphere and the COSmos – BIOCOS (coordinated at the Halberg Chronobiology Center)

• Members of the IEEE Twin Cities Phoenix Project

• Engr. Larry A Beaty serves as adviser and consultant to the Halberg Chronobiology Center

• Drs Francine and Julia Halberg are advisory board members of the Halberg Chronobiology Center


Multi-Ethnic Study of Atherosclerosis (MESA)

Mini Symposium Remembering Franz Halberg
May 19, 2017

Noninvasive Methods in Cardiology, Brno, Czech Republic

European Space Weather Week Conference, Brussels, Belgium
  Presenting Keynote, Cornelissen
  Invited Speech

Conference on Chronomedicine, 2015, Ahamabad, India
  Presentation, Cornelissen
  Presentation, Lee Gierke

Conference on Chronomedicine, 2016, Lucknow, India
  Presentation, Cornelissen
  Presentation, Lee Gierke

CardioPalooza (IBP dept) posters
2014: Lyazzat Gumarova 
2014: Cathy Lee Gierke 
2015: James Fleming 
2016: Shahrukh Rizvi 
2016: Tony Tran 
2016: Cathy Lee Gierke 
2017: Lyazzat Gumarova 
2017: Zainab Farah 
2019: Lyazzat Gumarova 

MN Stroke Conference, MN Dept of Health
2016: Poster, Germaine Cornelissen
2017: Presentation, Germaine Cornelissen

Gordon Conference on Chronobiology, Girona, Spain 
2015: Poster, Cathy Lee Gierke

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