Halberg Chronobiology Center

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Science objectively quantifying and investigating mechanisms of biologic time structure, including rhythmic manifestations of life. more...

Chronomics (from Greek chronos, time, and Greek nomos, rule)

Science objectively quantifying and investigating influences from the broad environment on biological processes, notably in relation to human physiology and pathology. more...


To serve as an expert facility for research and education in chronobiology as it applies to cardiology


  • To use timing according to rhythms (chronobiologic principles) for assessing cardiovascular health, detect pre-disease early, and optimize treatment administration schedules, in order to reduce the number of people who die of preventable heart attacks and strokes

  • To understand how blood pressure and heart rate vary in response to stimuli in everyday life for health surveillance and maintenance

  • To explore how solar cycles and changes in the Earth’s radiation environment affect human physiology as their impact may have implications for long-term missions in space

2019 Annual Scientific Report published in Leibnitz Society of Sciences

2018 Annual Scientific Report published in International Academy of Sciences

2017 Annual Scientific Report

2016 Annual Scientific Report

2015 Annual Scientific Report published in Leibnitz Society of Sciences

2014 Annual Scientific Report published in La Clinica Terapeutica

Recent Publications:

Otsuka K, Cornelissen G, Kubo Y, Shibata K, Mizuno K, Hoshima H, Furukawa S, Mulai C. Anti-aging effects of long-term space missions, estimated by heart rate variability. Scientific Reports https://rdcu.be/bHk6n

Cornelissen G, Watanabe W, Siegelova J, Beaty LA, Singh RK, Singh R, Singh RB, Delcourt A, Gumarova L, Gubin D, Chen CH, Otsuka K, for Investigators of the Project on the BIOsphere and the COSmos (BIOCOS) and Members of the Phoenix Study Group. Chronobiologically interpreted ambulatory blood pressure monitoring: past, present, and future. Biological Rhythm Research 2018; DOI: 10.1080/09291016.2018.1491193

Otsuka K, Cornelissen G, Kubo Y, Shibata K, Hayashi M, Mizuno K, Ohshima H, Furukawa S, Mukai C. Circadian challenge of astronauts’ unconscious mind adapting to microgravity in space, estimated by heart rate variability. Scientific Reports 2018; DOI:10.1038/s41598-018-28740-z

Sletten J, Cornelissen G, Assmus J, Kiserud T, Albrechtsen S, Kessler J. Maternal exercise, season and sex modify the daily fetal heart rate rhythm. Acta Physiologica 2018; 224 (2): e13093. doi: 10.1111/apha.13093.

Cornelissen G. Metabolic syndrome, adiponectin, sleep, and the circadian system. EBioMedicine 2018; 33: 20-21. doi: 10.1016/j.ebiom.2018.06.013.

Wanliss J, Cornélissen G, Halberg F, Brown D. Superposed epoch analysis of physiological fluctuations: possible space weather connections. Int J Biometeorology 2017. doi: 10.1007/s00484-017-1453-7.

Gubin D, Nelaeva AA, Uzhakova AE, Hasanova YV, Cornélissen G, Weinert D. Disrupted circadian rhythms of body temperature, heart rate and fasting blood glucose in prediabetes and type 2 diabetes mellitus. Chronobiology International 2017; 34 (8):1136-1148.

Otsuka K, Cornélissen G, Halberg F. Chronomics and Continuous Ambulatory Blood Pressure Monitoring – Vascular Chronomics: From 7-Day/24-Hour to Lifelong Monitoring. Tokyo: Springer Japan, 2016, 870 + lxxv pp. 10.1007/978-4-431-54631-3.

Cornélissen G, Otsuka K. Chronobiology of aging: a mini-review. Gerontology 2017; 63 (2): 118-128. DOI: 10.1159/000450945. – By invitation

Otsuka K, Cornélissen G, Furukawa S, Kubo Y, Hayashi M, Shibata K, Mizuno K, Aiba T, Ohshima H, Mukai C. Long-term exposure to space’s microgravity alters the time structure of heart rate variability of astronauts. Heliyon 2016; 2 (12): e00211. http://dx.doi.org/10.1016/j.heliyon.2016.e00211.

Kushwaha RS, Gupta RC, Sharma JP, Sharma S, Singh RK, Cornélissen G. Circadian periodicity of circulating plasma lipid peroxides, uric acid and ascorbic acid in renal stone formers. Ind J Clin Biochem 2017; 32 (2): 220-224.

He Y, Cornélissen-Guillaume GG, He JY, Kastin AJ, Harrison L, Pan W. Circadian rhythm of autophagy proteins in hippocampus is blunted by sleep fragmentation. Chronobiology int 2016; 33 (5): 553-560.

Singh R, Sharma S, Singh RK, Mahdi AA, Singh RK, Lee Gierke C, Cornélissen G. Effect of gender, age, diet and smoking status onchronomics of circulating plasma lipid components in healthy Indians. Clinica Chimica Acta 2016; 459: 10-18.

Cornélissen G. Statement from the American Statistical Association regarding statistical significance and P-values – a chronobiologist’s comments. World Heart J 2016; 8 (3): 197-201.

Cornélissen G, Singh R, Singh RK, Singh RB, de Meester F. Some chronobiological investigations relevant to cholesterol. In: Watson RR, de Meester F, eds. Handbook of cholesterol: Biology, function and role in health and diseases. Wageningen, The Netherlands: Wageningen Academic Publishers; 2016. pp. 203-233.

Lee Gierke C, Cornélissen G. Chronomics analysis toolkit (CATkit). Biological Rhythm Research 2016; 47: 163-181.

Otsuka K, Cornélissen G, Kubo Y, Hayashi M, Yamamoto N, Shibata K, Aiba T, Furukawa S, Ohshima H, Mukai C. Intrinsic cardiovascular autonomic regulatory system of astronauts exposed long-term to microgravity in space: observational study. npj Microgravity 2015; 1: 15018. doi:10.1038/npjmgrav.2015.18.

Okajima K, Yamanaka G, Oinuma S, Kikichi T, Yamanaka T, Otsuka K, Cornélissen G. Even mild depression is associated with among-day blood pressure variability, including masked non-dipping assessed by 7-d/24-h ambulatory blood pressure monitoring. Clin Exp Hypertens 2015; 37 (5): 426-432.

Kikuchi T, Okajima K, Cornélissen G, Sasaki J, Oinuma S, Yamanaka G, Okumiya K, Matsubayashi K, Yamanaka T, Otsuka K. Community-based comprehensive geriatric assessment of short- and long-term predictors of cognitive decline in elderly adults. J Am Geriatrics Soc 2015; 63 (5): 1031-1033.

Brat K, Homolka P, Cornélissen G, Merta Z, Homolka M, Rihucek I, Sevcik P. Chronobiological analysis of changes in arterial blood pressure in participants of the 5th and 6th Czech Antarctic Scientific Expeditions. Neuroendocrinol Lett 2015; 36 (1): 80-83.

Cornélissen G, Watanabe Y, Otsuka K, Halberg F. Influences of space and terrestrial weather on human physiology and pathology. In: Rosch PJ (Ed.) Bioelectromagnetic and Subtle Energy Medicine, 2nd ed. Boca Raton: CRC Press; 2015. pp. 389-400.

Cheng S, Jiang Z, Wang Z, Cornélissen G. Non-transcriptional/translational regulations of the circadian system. Biological Rhythm Research 2015; 46 (4): 471-481.

Okajima K, Otsuka K, Oinuma S, Sasaki J, Yamanaka T, Cornélissen G. Aging and within- and between-day variability assessed using 7-day/24-hour ambulatory blood pressure monitoring. J Am Geriatrics Soc 2014; 42 (12): 2440-2442.

Otsuka K, Okajima K, Oinuma S, Sasaki J, Yamanaka T, Takahashi Y, Kokuji A, Kitamura K, Cornélissen G. Aging and circadian disruption of blood pressure observed using 7-day/24-hour ambulatory blood pressure monitoring. J Am Geriatrics Soc 2014; 62 (11): 2213-2215.

Otsuka K, Okajima K, Yamanaka T, Oinuma S, Sasaki J, Taniwaki Y, Otsuka K, Cornélissen G. Aging and the novelty pressor effect in men on the first day of 7-day/24-hour ambulatory blood pressure monitoring. J Am Geriatrics Soc 2014; 62 (8): 1602-1605.

Syutkina EV, Kozhevnikova OV, Namazova-Baranova LS, Smirnov IE, Masalov AV, Cornélissen G, Schwartzkopff O, Mitish MD, Gumarova L, Halberg F. Vascular variability anomalies (VVAs) in children. J Appl Biomed 2014; 12: 147-153.

Zeng W, Liang X, Wan C, Wang Y, Jiang Z, Cheng S, Cornélissen G, Halberg F, Wang Z. Patterns of mortality from cardiac-cerebral vascular disease and influences from the cosmos. Biological Rhythm Research 2014; 45: 579-589.

Cornélissen G. Cosinor-based rhythmometry. Theoretical Biology and Medical Modelling 2014; 11: 16. doi:10.1186/1742-4682-11-16. 24 pp.

Cornélissen G, Otsuka K, Halberg F. Remove and replace for a scrutiny of space weather and human affairs. In: Grigoriev AI, Zeleny LM. (Eds.) Proceedings, International Conference, Space Weather Effects in Humans: In Space and on Earth, Space Research Institute, Moscow, Russia, June 4-8, 2012. 2013; 508-538.

Hsuchou H, Wang Y, Cornélissen-Guillaume GG, Kastin AJ, Jang E, Halberg F, Pan W. Diminished leptin signaling can alter circadian rhythm of metabolic activity and feeding. J Appl Physiol 2013; 115: 995-1003.

Halberg F, Powell D, Otsuka K, Watanabe Y, Beaty LA, Rosch P, Czaplicki J, Hillman D, Schwartzkopff O, Cornélissen G. Diagnosing vascular variability anomalies, not only MESOR-hypertension. Am J Physiol Heart Circ Physiol 2013; 305: H279-H294.

Watanabe Y, Halberg F, Otsuka K, Cornélissen G. Toward a personalized chronotherapy of high blood pressure and a circadian overswing. Clin Exp Hypertens 2013; 35 (4): 257-266.

Jayaram B, Pan W, Wang Y, Hsuchou H, Mace A, Cornélissen-Guillame GG, Mishra PK, Koza RA, Kastin AJ. Astrocytic leptin receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity. J Appl Physiol 2013; 114(6): 734-741.

Pan W, Hsuchou H, Cornélissen-Guillaume GG, Jayaram B, Wang Y, Tu H, Halberg F, Wu X, Chua SC Jr, Kastin AJ. Endothelial leptin receptor mutation provides partial resistance to diet-induced obesity. J Appl Physiol 2012; 112: 1410-1418.

Jiang Z, Li W, Liu Y, Wang Y, Wang Z, Xiao J, Guo H, Cornélissen G, Halberg F. Circadian blood pressure and heart rate characteristics in haemorrhagic vs ischaemic stroke in Chinese people. J Hum Hypertens 2010; 24: 165-174.

Refinetti R, Cornélissen G, Halberg F. Procedures for numerical analysis of circadian rhythms. Biological Rhythm Research 2007; 38 (4): 275-325.

Hua H, Wang YQ, Wan CM, Liu YY, Zhu B, Yang CL, Wang XJ, Wang ZR, Cornélissen-Guillaume G, Halberg F. Circadian gene mPer2 overexpression induces cancer cell apoptosis. Cancer Science 2006; 97 (7): 589-596.


Key Collaborators:

• Professor Kuniaki Otsuka, MD, PhD, Chronomics and Gerontology;

• Associate Professor Yoshihiko Watanabe, MD, PhD, Medicine, Tokyo Women’s Medical University, Medical Center East, Tokyo, Japan

• Professor Jarmila Siegelova, MD, Physiotherapy and Rehabilitation, St Anna Teaching Hospital, Masaryk University, Brno, Czech Republic

• Associate Professor Lyazzat Gumarova, PhD, Al-Farabi Kazakh National University, Almaty, Kazakhstan

• Professor Weihong Pan Biopotentials Sleep Center, Baton Rouge, Louisianna

• Dr Ram B Singh, MD, Halberg Hospital and Research Institute, Centre of Nutrition and Heart Research, Moradabad, India

• Members of the International Project on The BIOsphere and the COSmos – BIOCOS (coordinated at the Halberg Chronobiology Center)

• Members of the IEEE Twin Cities Phoenix Project

• Engr. Larry A Beaty serves as adviser and consultant to the Halberg Chronobiology Center

• Drs Francine and Julia Halberg are advisory board members of the Halberg Chronobiology Center


Centenary Lecture for Franz Halberg

April 29, 2019

Mini Symposium Remembering Franz Halberg

May 19, 2017


Noninvasive Methods in Cardiology, Brno, Czech Republic


European Space Weather Week Conference, Brussels, Belgium

Presenting Keynote

Invited Speech

Conference on Chronomedicine, 2016, Lucknow, India

Poster, Cathy Gierke

Poster, Shahrukh Rizvi

Poster, Tony Tran

CardioPalooza, 2016

University of MN


MN Stroke Conference, MN Dept of Health, June 2016, Minneapolis, MN


Keynote lecture

Invited Speech at Intnl Congress Indian Society of Chronomedicine, Nov 2015, Ahmadebad, India


Gordon Conference on Chronobiology, June 2015, Girona, Spain

Poster, James Fleming

Poster, Cathy Gierke

CardioPalooza, 2015

University of MN

Resolution of the SIRMCE Conference

Cosinor technique:

A legacy in Time:

Franz Halberg's motto, "Measure what is measurable and render measurable in time what as yet is not" (Omnia metire quaecumque licet et immensa ad mensuram tempestive redige), has also been attributed to Galileo according to Giovanni dell' Acqua, the late professor of medicine at Catholic University in Rome.

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