Halberg Chronobiology Center

Measure what is measurable and render measurable in time what as yet is not


Chronomics and Continuous Ambulatory Blood Pressure Monitoring

Resolution of the SIRMCE Conference

Cosinor technique:

A legacy in Time:

Franz Halberg's motto, "Measure what is measurable and render measurable in time what as yet is not" (Omnia metire quaecumque licet et immensa ad mensuram tempestive redige), has also been attributed to Galileo according to Giovanni dell' Acqua, the late professor of medicine at Catholic University in Rome.

Related Links:


Science objectively quantifying and investigating mechanisms of biologic time structure, including rhythmic manifestations of life.  more...

Chronomics (from Greek chronos, time, and Greek nomos, rule)

Science objectively quantifying and investigating influences from the broad environment on biological processes, notably in relation to human physiology and pathology.  more...


To serve as an expert facility for research and education in chronobiology as it applies to cardiology

  • To use timing according to rhythms (chronobiologic principles) for assessing  cardiovascular health, detect pre-disease early, and optimize treatment administration schedules, in order to reduce the number of people who die of preventable heart attacks and strokes

  • To understand how blood pressure and heart rate vary in response to stimuli in everyday life for health surveillance and maintenance

  • To explore how solar cycles and changes in the Earth’s radiation environment affect human physiology as their impact may have implications for long-term missions in space

Recent Publications:

Otsuka K, Cornelissen G, and Halberg F. Chronomics and Continuous Ambulatory Blood Pressure Monitoring. Tokyo: Springer Japan, 2016. 10.1007/978-4-431-54631-3.

Otsuka K, Cornelissen G, Kubo Y, Hayashi M, Yamamoto N, Shibata K, Aiba T, Furukawa S, Ohshima H, Mukai C. Intrinsic cardiovascular autonomic regulatory system of astronauts exposed long-term to microgravity in space: observational study. npj Microgravity 2015; 1: 15018. doi:10.1038/npjmgrav.2015.18

Lee Gierke C, Cornelissen G. Chronomics analysis toolkit (CATkit). Biological Rhythm Research 2015. :1–19. doi: 10.1080/09291016.2015.1094965

Okajima K, Yamanaka G, Oinuma S, Kikichi T, Yamanaka T, Otsuka K, Cornélissen G. Even mild depression is associated with among-day blood pressure variability, including masked non-dipping assessed by 7-d/24-h ambulatory blood pressure monitoring. Clin Exp Hypertens 2015; posted online March 27, 2015. 7 pp. doi: 10.3109/10641963.2015.1013114.

Kikuchi T, Okajima K, Cornélissen G, Sasaki J, Oinuma S, Yamanaka G, Okumiya K, Matsubayashi K, Yamanaka T, Otsuka K. Community-based comprehensive geriatric assessment of short- and long-term predictors of cognitive decline in elderly adults. J Am Geriatrics Soc 2015; 63 (5): 1031-1033.

Cornélissen G, Lee Gierke C, Watanabe Y, Beaty LA, Siegelova J, Delcourt A, Deruyck C, Singh RB, Revilla MA, Otsuka K, on behalf of the Project on the Biosphere and the Cosmos (BIOCOS). World Heart J 2015; 7 (2): 107-117.

Cheng S, Jiang Z, Wang Z, Cornélissen G. Non-transcriptional/translational regulations of the circadian system. Biological Rhythm Research 2015; 46 (4): 471-481. DOI: 10.1080/09291016.2015.1020203.

Cornélissen G. Prediction and prevention. International Innovation 2015; Issue 181: 77-79. http://www.internationalinnovation.com/prediction-and-prevention/

Brat K, Homolka P, Cornélissen G, Merta Z, Homolka M, Rihucek I, Sevcik P. Chronobiological analysis of changes in arterial blood pressure in participants of the 5th and 6th Czech Antarctic Scientific Expeditions. Neuroendocrinol Lett 2015; 36 (1): 80-83. PMID 25789585.

Masood T, Kushwaha RS, Singh R, Sailwal S, Pandey H, Varma A, Singh RK, Cornélissen G. Circadian rhythm of serum 25 (OH) vitamin D, calcium and phosphorus levels in the treatment and management of type-2 diabetic patients. Drug Discoveries & Therapeutics 2015; 9 (1): 70-74. doi: 10.5582/ddt.2015.01002

Singh RB, Cornélissen G, Wilson DW, Dimitrov BD. Can Halberg's approach to chronotherapy improve world health? Arch Med Sci 2015; 11 (5): 3 pp.

Zeng W, Liang X, Wan C, Wang Y, Jiang Z, Cheng S, Cornélissen G, Halberg F, Wang Z. Patterns of mortality from cardiac-cerebral vascular disease and influences from the cosmos. Biological Rhythm Research 2014; 45 (4): 579-589. doi: 10.1080/09291016.2013.876189

Okajima K, Otsuka K, Oinuma S, Sasaki J, Yamanaka T, Cornélissen G. Aging and within- and between-day variability assessed using 7-day/24-hour ambulatory blood pressure monitoring. J Am Geriatrics Soc 2014; 42 (12): 2440-2442.

Hristova K, Cornélissen G, Fedacko J, Singh RB. Echocardiographic study of circadian myocardial function among clinically healthy subjects. World Heart Journal 2014; 6 (4): 241-259.

Watanabe Y, Halberg F, Kikuchi T, Mitsuhashi T, Otsuka K, Sakura H, Cornélissen G. Earthquake and ambulatory blood pressure monitoring. J Phys Fitness Sports Med 2014; 3 (5): 507-508.

Otsuka K, Okajima K, Oinuma S, Sasaki J, Yamanaka T, Takahashi Y, Kokuji A, Kitamura K, Cornélissen G. Aging and circadian disruption of blood pressure observed using 7-day/24-hour ambulatory blood pressure monitoring. J Am Geriatrics Soc 2014; 62 (11): 2213-2215.

Otsuka K, Okajima K, Yamanaka T, Oinuma S, Sasaki J, Taniwaki Y, Otsuka K, Cornélissen G. Aging and the novelty pressor effect in men on the first day of 7-day/24-hour ambulatory blood pressure monitoring. J Am Geriatrics Soc 2014; 62 (8): 1602-1605.

Otsuka K, Cornélissen G, Yamanaka T, Oinuma S, Sasaki J, Yamanaka G, Okumiya K, Matsubayashi K. Time estimation predicts improvement in cognitive function in elderly community-dwelling adults. J Am Geriatrics Soc 2014; 62 (5): 974-976.

Otsuka K, Cornélissen G, Yamanaka T, Oinuma S, Sasaki J, Yamanaka G, Okumiya K, Matsubayashi K. Comprehensive geriatric assessment reveals sleep disturbances in community-dwelling elderly adults associated with even slight cognitive decline. J Am Geriatrics Soc 2014; 62 (3): 571-573.

Otsuka K, Okajima K, Yamanaka T, Cornélissen G. Vascular variability syndromes. Nippon Rinsho 2014; 72 (8): 1491-1496.

Hristova K, Shiue I, Pella D, Singh RB, Chaves H, Basu TK, Ozimek L, Rastogi SS, Takahashi T, Wilson D, DeMeester F, Cheema S, Garg M, Buttar HS, Milovanovic B, Kumar A, Handjiev S, Cornélissen G, Petrov I. Sofia Declaration on transition of prevention strategies for cardiovascular diseases and diabetes mellitus in developing countries: a statement from the International College of Cardiology and International College of Nutrition. Nutrition 2014.

Kumar A, Kaur H, Singh RB, Cornélissen-Guillaume G, Attri A. Gender-specific issues in coronary artery disease. World Heart Journal 2014; 6 (2): 123-138.

Cornélissen G. Cosinor-based rhythmometry. Theoretical Biology and Medical Modelling 2014; 11: 16. 24 pp. 


Key Collaborators:

• Professor Kuniaki Otsuka, MD, PhD, Chronomics and Gerontology; 

• Associate Professor Yoshihiko Watanabe, MD, PhD, Medicine, Tokyo Women’s Medical University, Medical Center East, Tokyo, Japan 

• Professor Jarmila Siegelova, MD, Physiotherapy and Rehabilitation, St Anna Teaching Hospital, Masaryk University, Brno, Czech Republic 

• Associate Professor Lyazzat Gumarova, PhD, Al-Farabi Kazakh National University, Almaty, Kazakhstan 

 Professor Weihong Pan Biopotentials Sleep Center, Baton Rouge, Louisianna

• Dr Ram B Singh, MD, Halberg Hospital and Research Institute, Centre of Nutrition and Heart Research, Moradabad, India
• Members of the International Project on The BIOsphere and the COSmos – BIOCOS (coordinated 
at the Halberg Chronobiology Center) 

• Members of the IEEE Twin Cities Phoenix Project 

• Drs Francine and Julia Halberg serve as advisors to the Halberg Chronobiology Center 

• CATkit: Chronomics Analysis Toolkit in R


MN Stroke Conference, MN Dept of Health, June 2016, Minneapolis, MN

Franz Halberg lecture
at 8th Intnl Conf on Cardiovascular Diseases  Aug 2015,  Recife, Brazil

Keynote lecture at Intnl Congress Indian Society of Chronomedicine, Nov 2015, Dehradun, India

Gordon Conference on Chronobiology, June 2015, Girona, Spain 

Poster, James Fleming
Poster, Cathy Gierke
CardioPalooza, 2015
University of MN